Donald Gagné, Ph.D., is a Postdoctoral Researcher in the Gardner laboratory. Over the course of his professional career, he has been privileged to participate in multidisciplinary research programs in biochemistry and molecular biology. Currently, one of the most exciting advancements in the field is the rapid development of biophysical techniques that allow observation of protein motions involved in protein-ligand interaction and allosteric responses. Despite the discipline being in its relative infancy, the application of protein motions is significant in our understanding of the mechanistic details relative to protein function. Donald developed expertise in NMR spectroscopy and X-ray crystallography, two complementary fields that provide him with the knowledge in the study of protein interactions.
Donald earned his B.S. in biochemistry from Laval University, Canada (B.S. Biochemistry, 1990), and a master’s degree in physiology-endocrinology (M.S. Biochemistry, 1994) on the regulation of expression of the FAR-17A gene in the hamster flank organs, under the direction of Fernand Labrie at Laval University. After sharing his time between the academic and pharmaceutical sectors, Donald completed a doctoral thesis on the conservation and modulation of functional dynamic sectors in ribonucleases homologues, under the mentoring of Nicolas Doucet at INRS Institut Armand-Frappier, Canada (Ph.D. Biology, 2015).
Protein-ligand interactions, protein motions, and allostery.